Werdegang:
Ausbildung:
1962 Polytechnische Oberschule Pegau/Leipzig
1962-1964 Abitur an der Volkshochschule Leipzig (Abendoberschule) und Lehre als Landwirt (Saatzucht) an der Versuchsstation Seehausen der Universität Leipzig (Facharbeiterabschluss)
1964-1969 Biologiestudium an der Ernst-Moritz-Arndt-Universität Greifswald
1969 Diplom (Biologie/Genetik) an der Universität Greifswald
1974 Promotion (Dr. rer.nat.) an der Martin-Luther-Universität Halle-Wittenberg
Berufliche Tätigkeiten:
1969-1978 Wissenschaftliche Mitarbeiterin in der Abt. Zytogenetik am Institut für Kulturpflanzenforschung der Akademie der Wissenschaften Gatersleben
1978-1991 Wissenschaftliche Mitarbeiterin in der Abt. für Entwicklungsbiologie am Institut für Genetik und Kulturpflanzenforschung Gatersleben der Akademie der Wissenschaften
01.01.1992 Leiterin der Forschungsgruppe "In Vitro Differenzierung" am neugegründeten Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK) Gatersleben
1997 Habilitation und Venia legendi im Fach Zellbiologie an der Medizinischen Fakultät der Martin-Luther-Universität Halle-Wittenberg (“Privatdozent”)
1997-2011 Vorlesungen und Kurse zu “Grundlagen der Zell- und Gewebekultur“ und “Stammzellfoschung” am IPK Gatersleben und der Universität Halle
2001-2007 Dozent im MD/PhD-Programm “Molecular Medicine“ an der Medizinischen Hochschule (MH) Hannover
2004 Professur (apl) an der Medizinischen Fakultät der Martin-Luther-Universität Halle-Wittenberg
2011-2020 externer Senior-Gastwissenschaftler am IPK Gatersleben
Forschungsschwerpunkte:
Biologie embryonaler Stammzellen: Regulation der Differenzierung pluripotenter embryonaler Stammzellen, in vitro-Differenzierung in kardiale, neurale, pankreatische und hepatische Zellen
Kultivierung, Modifikation und Differenzierung somatischer Stamm- und Vorläuferzellen
In vitro-Toxikologie: Einsatz embryonaler Stammzellen für die Analyse toxischer Effekte von chemischen und physikalischen Faktoren. Geschichte der Stammzellforschung
Mitgliedschaften und Funktionen:
Berufliche Aktivitäten, Mitglied in Kommissionen (Auswahl):
1991-1997 Vize-Präsidentin der Deutschen Gesellschaft für Zell- und Gewebezüchtung (GZG) in der European Tissue Culture Society (ETCS)
1992-1995 Stellvertretendes Mitglied (Zellbiologie) in der Zentralen Kommission für Biologische Sicherheit (ZKBS)
1992-1994 Mitglied des “Standing Committee for Ethical Questions of the International Network of Engineers and Scientists for Global Responsibility” (INES)
1993-2000 Mitglied des Naturschutzbeirats des Ministers für Natur- und Umweltschutz Sachsen-Anhalt
1997-2006 Council Member der European Tissue Culture Society (ETCS)
1999-2001 Vize-Präsidentin der Deutschen Gesellschaft für Zellbiologie (DGZ)
1999 Gast-Editor der Zeitschrift “Cells Tissues Organs” (Karger, Basel) für den Band "ES Cells as Developmental Model in vitro“
1999-2014 Mitglied des Editorial Board, seit 2004 Associate Editor, von "Cells Tissues Organs" (CTO, Karger, Basel)
1999-2007 Mitglied der Kommission “Humane Embryonale Stammzellen“ der Deutschen Forschungsgemeinschaft (DFG)
2000-2007 Koordinator des Schwerpunktprogramms 1109 der DFG “Embryonale und Somatische Stammzellen - Regenerative Systeme für Zell- und Gewebeersatz“
2001-2005 Mitglied des Wissenschaftlichen Beirats der CDU/CSU-Fraktion des Deutschen Bundestages
2001-2010 Mitglied des Editorial Board des “International Journal of Developmental Biology" (The University of the Basque Country Press, Bilbao, Spain)
2002-2014 Mitglied des ‘Novartis Ethics Advisory Board’ (NEAB), NOVARTIS Pharma International, Basel
2002-2020 Mitglied der Zentralen Ethik-Kommission für Stammzellenforschung (ZES), seit 2008 Stellvertretende Vorsitzende
2005-2011 Mitglied des Editorial Board von "Stem Cells" (AlphaMed Press, Durham, NC, USA)
2005-2010 Mitglied der Arbeitsgruppe "Gentechnologie-Report“ der Berlin-Brandenburgischen Akademie der Wissenschaften (BBAW)
2006-2011 Mitglied des Editorial Board des "Journal of Stem Cells" (Nova Science Publishers, Inc., New York)
2006 Gast-Editor des Handbook of Experimental Pharmacology, vol. 174: "Stem Cells”, 2nd edition in 2008
2006-2011 Mitglied des Wissenschaftlichen Beirats des Wissenschaftszentrums Wittenberg, Sachsen-Anhalt
2007-2011 Mitglied des Editorial Board des "Journal of Tissue Engineering and Regenerative Medicine" (John Wiley & Sons, Ltd. UK)
Mitglied in wissenschaftlichen Akademien:
2001 Mitglied der Nationalen Akademie der Wissenschaften LEOPOLDINA
2002 Mitglied der Berlin-Brandenburgischen Akademie der Wissenschaften (BBAW)
2010 Mitglied der European Academy of Sciences and Arts (Salzburg)
2014 Korrespondierendes Mitglied der Nordrhein-Westfälischen Akademie der Wissenschaften und Künste
Organisation von Konferenzen, Meetings und Workshops (Auswahl):
1986-2011 Co-Organisation von interdisziplinären Tagungen zu den Folgen von Wissenschaft und neuen Technologien organisiert vom IPK Gatersleben und (zwischen 1995-2013) in Zusammenarbeit mit der Nationalen Akademie der Wissenschaften LEOPOLDINA ("Gaterslebener Begegnungen")
1994-2004 Organisation/Co-Organisation nationaler und internationaler Konferenzen, Symposien und Workshops auf den Gebieten der Zellbiologie und der Stammzellforschung (z.B. World Congress “Alternatives and Animal Use in the Life Sciences“, Utrecht/1996, Bologna/1999; ETCS-Meetings in Prag/1994, Mainz/1997, Granada/2001, Münster/2004; DGZ-Meetings in Halle/1997, Karlsruhe/ 2000, Jena/2000, Potsdam/2001, Strasbourg/2001, Jena/2002;
3rd ELSO-Meeting 2003, Dresden; European Congress der International Society of Heart Research (ISHR), Dresden, 2004; World Congress of the ISHR, Brisbane, Australien, 2004)
2001-2005 Organisation von fünf Annual Meetings des DFG-Schwerpunktprogramms 1109 zur Stammzellforschung
2006 Organisation der Internationalen Konferenz der DFG und der Nationalen Akademie der Wissenschaften LEOPOLDINA zu "Embryonic and Somatic Stem Cells - Regenerative Systems for Cell and Tissue Repair", Dresden
2006-2010 Co-Organisation der “Gaterslebener Gespräche” in Kooperation mit Ulrich Wobus am IPK Gatersleben mit der Evangelischen Akademie Wittenberg
2015, 2017 Fortsetzung der „Gaterslebener Gespräche“ am IPK Gatersleben (mit Ulrich Wobus)
Auszeichnungen und Ehrungen:
1991 "Hildegard Doerenkamp-Gerard Zbinden Award for Realistic Animal Protection in Scientific Research", Schweiz
1991 "Tierschutz-Forschungspreis" des Gesundheits-Ministers der Bundesrepublik Deutschland (mit Jürgen Hescheler und Gerd Wallukat)
2001 "Felix-Wankel-Tierschutz-Forschungspreis", Deutschland
2003 Forschungspreis des Stifterverbands für die Deutsche Wissenschaft
2011 Cothenius-Medaille der Nationalen Akademie der Wissenschaften LEOPOLDINA (mit Ulrich Wobus)
Ausgewählte Publikationen:
1969 - 1990
Knietsch, A. M. (1969): Induktion von Mutationen und Charakterisierung der Mutanten von Claviceps purpurea. Diploma Thesis, Ernst-Moritz-Arndt-Universität Greifswald.
Wobus, A. M. (1974): Vergleichende Untersuchungen über die Induktion von Chromosomen-aberrationen an cytogenetischen Testsystemen in vivo und in vitro im Rahmen von Mutagenitätsprüfungen. Doctoral Thesis, Martin-Luther-Universität Halle-Wittenberg.
Wobus, A. M. (1976): Clastogenic activity of cytosine arabinoside and 3'-deoxy-3'-fluorothymidine in Ehrlich ascites tumour cells in vitro. Mut. Res. 40:101 - 106.
Wobus, A. M., R. Thieme and J. Schöneich (1977): The influence of the mode of administration of mutagens on the aberration frequency of mouse bone marrow and ascites tumour cells. Mut. Res. 46:242.
Wobus, A. M., U. Wobus and J. Schöneich (1977): Effects of the antibiotic netropsin on mouse ascites tumour chromosomes in vitro. Experientia 33:1212 - 1213.
Wobus, A. M. and J. Schöneich (1977): Ein zytologisches Testsystem zur routinemäßigen Mutagenitätsprüfung. Pharmazie 32:178 - 180.
Wobus, A. M., J. Schöneich and R. Thieme (1978): The effect of the mode of administration of nitrogen mustard and cytosine arabinoside on the production of chromosomal aberrations in mouse bone marrow and ascites tumour cells. Mut. Res. 58:67 - 77.
Thieme-Creutziger, R., A. M. Wobus and J. Schöneich (1979): Effects of the mode of administration of Mitomycin C on the production of chromatid structural changes in bone marrow and ascites tumour cells of mice. Biolog. Zentralbl. 98:711 - 717.
Wobus, A. M., G. Walter, K. Becker and J. Schöneich (1982): Teratokarzinome der Maus - Modell zum Studium von Embryogenese und Zelldifferenzierung. Biol. Rundschau 20:147 - 151.
Jäkel, H., A. M. Wobus, C. Bloch, N. Jäkel and J. Schöneich (1983): A micromethod for the determination of alkaline phosphatase in mammalian cells. Biomed. Biochim. Acta 42:1123 - 1128.
Wobus, A. M., H. Holzhausen, P. Jäkel and J. Schöneich (1984): Characterization of a pluripotent stem cell line derived from a mouse embryo. Exp. Cell Res. 152:212 - 219.
Wobus, A. M., U. Kiessling, M. Strauss, H. Holzhausen and J. Schöneich (1984): DNA transformation of a pluripotent mouse embryonal stem cell line with a dominant selective marker. Cell Diff. 15:93 - 97.
Walter, G., A. Intek, A. M. Wobus and J. Schöneich (1984): Serological characterization of a pluripotent mouse embryonal stem cell line, two transformed derivatives, and an endoderm-like cell line. Cell Diff. 15:147 - 151.
Becker, K., A. M. Wobus, U. Conrad and J. Schöneich (1984): Injection of murine embryonal carcinoma cells and embryo-derived pluripotential cells into mouse blastocysts. Cell Diff. 15:195 - 202.
Wobus, A. M., H. Holzhausen, C. Bloch, A. Intek, K. Becker, G. Walter, J. Forejt and J. Schöneich (1985): Establishment and characterization of a pluripotent mouse teratocarcinoma cell line TCE. Biomed. Biochim. Acta 44:1609 - 1620.
Wobus, Anna M. (1985): Zuschriften an Erhard Geissler. Sinn und Form Heft 4, S. 904- 906.
Wobus, A. M. (1988): Wachstumsfaktor-verwandte Proteine in Drosophila - neue Vorstellungen über die Regulation zellulärer Differenzierungsprozesse. Biol. Rundschau 26:161 - 163.
Wobus, A. M., R. Grosse and J. Schöneich (1988): Specific effects of nerve growth factor on the differentiation pattern of mouse embryonic stem cells in vitro. Biomed. Biochim. Acta 47:965 - 973.
Lehmann, W., G. Sterba and A. M. Wobus (1989): Primary culture of the mouse subcommissural organ in vitro. Acta Zool. (Stockholm) 70:199 - 203.
Wobus, A. M., W. Zschiesche and R. Grosse (1990): Differentiation promoting effects of mammary - derived growth inhibitor (MDGI) on pluripotent mouse embryonic stem cells. Virchow's Arch. B Cell Pathol. 59:339 - 342.
1991
Wobus, A. M., G. Wallukat and J. Hescheler (1991): Pluripotent mouse embryonic stem cells are able to differentiate into cardiomyocytes expressing chronotropic responses to adrenergic and cholinergic agents and Ca2+ channel blockers. Differentiation 48:173 - 182.
Wallukat, G. and A. M. Wobus (1991): Use of spontaneously beating heart muscle cells differentiating from pluripotential embryonic stem cells for testing of chronotropic agents. Recent Developments in Toxicology: Trends, Methods and Problems, Arch. Toxicol. Suppl. 14:136 - 139.
Wobus, A.M. und U. Wobus (Hrsg.) "Genetik zwischen Furcht und Hoffnung". Urania Verlag, Leipzig, 164 S. (1991).
1992
Stahl, J., A. M. Wobus, S. Ihrig, G. Lutsch and H. Bielka (1992): The small heat shock protein hsp 25 is accumulated in embryonal carcinoma cells and embryonic stem cells during differentiation. Differentiation 51:33 - 37.
Wobus, A. M. und Jürgen Hescheler (1992): Entwicklung eines in vitro Herzzell-Modells für embryotoxikologische und pharmakologische Studien. Alternativen zu Tierexperimenten (ALTEX) 17:29 - 42.
1993
Wobus, A. M., V. Maltsev und J. Hescheler (1993): Aus pluripotenten embryonalen Stammzellen differenzierte Herzmuskelzellen als in vitro-System für pharmakologische und embryotoxikologische Studien. In: Schöffl, H., Spielmann, H., Tritthart, H.A. (Hrsg.): Ersatz- und Ergänzungsmethoden zu Tierversuchen, pp.110 - 120, Springer-Verlag Wien New York.
Kleppisch, T., A. M. Wobus and J. Hescheler (1993): Cation channels in oocytes and early states of development: a novel type of non-selective cation channel activated by adrenaline in a clonal mesoderm-like cell line (MES-1). In: Non-selective cation channels - Pharmacology, Physiology & Biophysics, Siemen, D. & J. Hescheler (Eds.), pp. 297 - 303, Birkhäuser Verlag Basel/ Switzerland.
Kleppisch, T., A. M. Wobus, C. Strübing and J. Hescheler (1993): Voltage-dependent L-type Ca channels and a novel type of non-selective cation channels activated by cAMP-dependent phosphorylation in mesoderm-like (MES-1) cells. Cellular Signalling 5:727 - 734.
Maltsev, V. A., J. Rohwedel, J. Hescheler and A. M. Wobus (1993): Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types. Mech. Dev. 44:41 - 50.
Maltsev, V. A., C. Strübing, A.M. Wobus and J. Hescheler (1993): In vitro - Differenzierung von Kardiomyozyten, Skelettmuskelzellen und Neuronen aus pluripotenten embryonalen Stammzellen. Tierlaboratorium 16:26 - 30.
1994
Rohwedel, J., V. Maltsev, E. Bober, H.-H. Arnold, J. Hescheler and A.M. Wobus (1994): Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: Developmentally regulated expression of myogenic determination genes and functional expression of ionic currents. Dev. Biol. 164:87 - 101.
Wobus, A.M., T. Kleppisch, V. Maltsev and J. Hescheler (1994): Cardiomyocyte-like cells differentiated in vitro from embryonic carcinoma cells P19 are characterized by functional expression of adrenoceptors and Ca2+ channels. In Vitro Cell & Developm. Biol. 30A:425 - 434.
Maltsev, V.A, A.M. Wobus, J. Rohwedel, M. Bader and J. Hescheler (1994): Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents. Circ. Res. 75:233 - 244.
Wobus, A.M., J. Rohwedel, V. Maltsev and J. Hescheler (1994): Embryonic stem cell-derived cardiogenesis and myogenesis. In: N. E. Fusenig and H. Graf (edts.) Cell Culture in Pharmaceutical Research. Ernst Schering Research Foundation Workshop 11, Springer-Verlag Berlin-Heidelberg-New York, p. 29 - 57.
Wobus, A.M., J. Rohwedel, V. Maltsev and J. Hescheler (1994): In vitro differentiation of embryonic stem cells into cardiomyocytes or skeletal muscle cells is specifically modulated by retinoic acid. Roux's Arch. Dev. Biol. 204:36 - 45.
Rose, O., J. Rohwedel, S. Reinhardt-Maelicke, M. Bachmann, M. Cramer, M. Rotter, A.M. Wobus and A. Starzinski-Powitz (1994): Expression of M-cadherin protein in myogenic cells during prenatal mouse development and differentiation of embryonic stem cells in culture. Developm. Dyn. 201:245 - 259.
Sehlmeyer, U. and A.M. Wobus (1994): Lower mutation frequencies are induced by ENU in undifferentiated embryonic cells than in differentiated cells of the mouse in vitro. Mut. Res. 324:69 - 76.
Prelle, K., Wobus, A.M., Wolf, E., Neubert, N. and Holtz, W. (1994) Effects of growth factors on the in vitro development of porcine inner cell masses isolated by calcium ionophore. J. Reprod. Fertil. 13: 41.
1995
Wobus, A.M., J. Rohwedel, V. Maltsev and J. Hescheler (1995): Development of cardiomyocytes expressing cardiac-specific genes, action potentials and ionic channels during embryonic stem cell-derived cardiogenesis. Ann. New York Acad. Sci. 752:460- 469.
Sehlmeyer, U. and A.M. Wobus (1995): MNNG is less cytotoxic and mutagenic in undifferentiated embryonic cells than in differentiated cells of the mouse in vitro. In Vitro Toxicol. 8:121-127.
Wobus, A.M., J. Rohwedel, V. Maltsev and J. Hescheler (1995): The developmental potential of embryonic stem cells - Cardiogenesis and myogenesis in vitro. J. Experim. Clin. Cancer Res. 14 (Suppl.):110 - 113.
Wobus, A.M., J. Rohwedel, V. Maltsev and J. Hescheler (1995): In vitro cellular models for cardiac development and pharmacotoxicology. Toxicol. In Vitro 9:477 - 488.
Strübing, C., A.M. Wobus and J. Hescheler (1995): Etablierung eines in vitro Modellsystems zur Differenzierung synaptisch verknüpfter Nervenzellen aus pluripotenten embryonalen Stammzellen der Maus. ALTEX 12:129 - 137.
Strübing, C., G. Ahnert-Hilger, Jin Shan, B. Wiedenmann, J. Hescheler and A.M. Wobus (1995): Differentiation of pluripotent embryonic stem (ES) cells into the neuronal lineage gives rise to mature inhibitory and excitatory neurons. Mech. Dev. 53:275 - 287.
Rohwedel, J., V. Horak, M. Hebrok, E.-M. Füchtbauer and A.M. Wobus (1995): M-twist expression inhibits mouse embryonic stem cell-derived myogenic differentiation in vitro. Exp. Cell Res. 220:92 - 100.
Knoll, A., V. Maltsev, A.M. Wobus and J. Hescheler (1995): Adenosine triphosphate-sensitive and inwardly rectifying potassium channels expressed in cardiomyocytes differentiated from embryonic stem cells. Heart Vessels, Suppl. 9:216 - 220.
1996
Sehlmeyer, U., A. Meister, W. Beisker and A.M. Wobus (1996): Low mutagenic effects of mitomycin C in undifferentiated embryonic P19 cells are correlated with efficient cell cycle control. Mut. Res. 354:103 - 112.
Bagutti, C., A.M. Wobus, R. Fässler and F. Watt (1996): Differentiation of embryonal stem cells into keratinocytes: Comparison of wild-type and ß1 integrin-deficient cells. Dev. Biol. 179:184 - 196.
Rohwedel, J., U. Sehlmeyer, Jin Shan, A. Meister and A.M. Wobus (1996): Primordial germ cell-derived mouse embryonic germ (EG) cells in vitro resemble undifferentiated stem cells with respect to differentiation capacity and cell cycle distribution. Cell Biol. Internat. 20:579 - 587.
Hescheler, J., V.A. Maltsev and A.M. Wobus (1996): Developmental Aspects of Cardiac Ion Channels. In: Morad, M., Ebashi, S., Trautwein, W. and Kurachi, Y. (Eds.) Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters. Kluwer Academic Publishers, Dordrecht Boston London, pp. 241 - 249.
Fässler, R., J. Rohwedel, V. Maltsev, W. Bloch, S. Lentini, Kaomei Guan, D. Gullberg, J. Hescheler, K. Addicks and A.M. Wobus (1996): Differentiation and integrity of cardiac muscle cells are impaired in the absence of ß1 integrin. J. Cell Sci. 109:2989 - 2999.
Sehlmeyer, U., J. Rohwedel and A.M. Wobus (1996): Primordial germ cell-derived embryonic germ cells of the mouse - in vitro model for cytotoxicity studies with chemical mutagens. Toxicol. in Vitro 10:755 - 763.
Wobus, A.M., U. Wobus und B. Parthier (Hrsg.) (1996) "Stellenwert von Wissenschaft und Forschung in der modernen Gesellschaft - Gaterslebener Begegnung 1995". Nova Acta Leopoldina, Neue Folge, Bd. 74, Nr. 297, 235 S.
1997
Wobus, A.M., J. Rohwedel, C. Strübing, Jin Shan, K. Adler, V. Maltsev and J. Hescheler (1997): In vitro differentiation of embryonic stem cells, In: S. Klug and R. Thiel (Eds.): Methods in Developmental Toxicology and Biology, Blackwell Wissenschaftsverlag Berlin Vienna, pp. 1-17.
Strübing, C., Ahnert-Hilger, G., B. Wiedenmann, J. Hescheler and A.M. Wobus (1997): Development of G-protein-mediated Ca2+ channel regulation in mouse embryonic stem cell-derived neurons. Europ. J. Neurosci. 9: 824 - 832.
Wobus, A.M., J. Rohwedel und U. Sehlmeyer (1997): Embryonale Stammzellen als Modellobjekt der Entwicklungsgenetik und Reproduktionsbiologie, In: Ersatz- und Ergänzungsmethoden zu Tierversuchen. Schöffl, H., H. Spielmann and H.A. Tritthart (Hrsg.), Springer-Verlag Wien New York, pp. 88 - 98.
Wobus, A.M. (1997): Embryonale Stammzellen der Maus in vitro - Modellobjekt der Entwicklungsbiologie und der genetischen Toxikologie. Habilitationsschrift, Mathematisch-Naturwissenschaftliche und Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg.
Wobus, A.M., Guan Kaomei, Jin Shan, M.-C. Wellner, J. Rohwedel, Ji Guanju, B. Fleischmann, H.A. Katus, J. Hescheler and W.-M. Franz (1997): Retinoic acid accelerates embryonic stem cell-derived cardiac differentiation and enhances development of ventricular cardiomyocytes. J. Mol. Cell. Cardiol. 29:1525-1539.
Drab, M., H. Haller, R. Bychkov, B. Erdmann, C. Lindschau, H. Haase, I. Morano, F.C. Luft and A.M. Wobus (1997): From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid db-cAMP in vitro differentiation model. FASEB J. 11: 905-915.
Wobus, A.M.: Zellkulturtechniken und Zellmodelle. In: Ganten, D. und K. Ruckpaul (Hrsg.) (1997) Handbuch der molekularen Medizin, Bd. 1, Molekular- und Zellbiologische Grundlagen, Springer-Verlag Berlin-Heidelberg-New York, pp. 305-337.
Pich, U., D. Pütz and A.M. Wobus (1997): Ein neues Screeningverfahren zur Messung chronotroper Effekte an Herzzellen - Entwicklung eines halbautomatischen Computer-gestützten Imaging Systems. BIOforum 20: 536-540.
Hescheler, J., B.K. Fleischmann, S. Lentini, V.A. Maltsev, J. Rohwedel, A.M. Wobus and K. Addicks (1997): Embryonic stem cells: A model to study structural and functional properties in cardiomyocytes. Cardiovasc. Res. 36: 149-162.
1998
Sauer, H., C. Hofmann, M. Wartenberg, A.M. Wobus and J. Hescheler (1998): Spontaneous calcium oscillations in embryonic stem (ES) cell-derived primitive endodermal cells. Exp. Cell Res. 238: 13-22.
Rohwedel, J., T. Kleppisch, U. Pich, K. Guan, S. Jin, W. Zuschratter, C. Hopf, W. Hoch, J. Hescheler, V. Witzemann and A.M. Wobus (1998): Formation of postsynaptic-like membranes during differentiation of embryonic stem cells in vitro. Exp. Cell Res. 239: 214-225.
Wobus, A.M. and K. Guan (1998): Embryonic stem cell-derived cardiac differentiation: Modulation of differentiation and 'loss of function' analysis in vitro. Trends Cardiovasc. Med. 8:64-74.
Wobus, A.M., Wobus, U. und B. Parthier (Hrsg.) (1998)"Vom Einfachen zur Ganzheitlichkeit - das Problem der Komplexität auf organismischer und kultureller Ebene", Gaterslebener Begegnung 1997", Nova Acta Leopoldina, Neue Folge, Bd. 77, Nr. 304.
Rohwedel, J., K. Guan, W. Zuschratter, S. Jin, G. Ahnert-Hilger, D. Fürst, R. Fässler and A.M. Wobus (1998): Loss of b1 integrin function results in a retardation of myogenic, but an acceleration of neuronal differentiation of embryonic stem cells in vitro. Dev. Biol. 201: 167-184.
Wobus, A.M., K. Guan, J. Rohwedel, C. Strübing and M. Drab (1998): Embryonic stem cell differentiation models: Cardiovascular, myogenic and neurogenic development in vitro. In: "New Developments and New Applications in Animal Cell Technology", Merten, O.W. et al. (eds.) Kluwer Academic Publishers, pp. 689-703.
1999
Guan, K., J. Rohwedel and A.M. Wobus (1999): Embryonic stem cell differentiation models: cardiogenesis, myogenesis, neurogenesis, epithelial and vascular smooth muscle cell differentiation in vitro. Cytotechnology 30:211-226.
Maltsev, V.A., Ji, G.J., Wobus, A.M., Fleischmann, B.K., and J. Hescheler (1999): Establishment of b-adrenergic modulation of L-type Ca2+ current in the early stages of cardiomyocyte development. Circ. Res. 84:136-145.
Guan K., M. Schmidt, Q. Ding, C. Hong and A.M. Wobus (1999): Embryonic stem cells in vitro - Prospects for cell and developmental biology, embryotoxicology and cell therapy. ALTEX 16:135-141.
Guan, K., Fürst, D. and A.M. Wobus (1999): Modulation of sarcomere organization during embryonic stem cell-derived cardiomyocyte differentiation. Europ. J. Cell Biol. 87: 813-823.
Rohwedel, J., K. Guan and A.M. Wobus (1999): Induction of cellular differentiation by retinoic acid in vitro. In: Wobus, A.M. & K. Boheler (eds.): Embryonic stem cells as developmental models, Karger, Switzerland, Special Issue of Cells Tissues Organs 165: 190-202.
Prelle, K., I.M. Vassiliev, S. Vassilieva, E. Wolf and A.M.Wobus (1999): Establishment of pluripotent cell lines from vertebrate species - present status and future prospects. In: Wobus, A.M. & K. Boheler (eds.): Embryonic stem cells as developmental models in vitro. Karger, Switzerland, Special Issue of Cells Tissues Organs 165: 220-236.
Wobus, A.M., E. Wolf and H.M. Beier (1999): Embryonic Stem Cells and Nuclear Transfer Strategies - Present State and Future Prospects. Biomed. Ethics 4: 110-111.
Wobus, A.M. and K.R. Boheler (Eds.) (1999): Embryonic Stem Cells as a Developmental Model in vitro. Special Issue Cells Tissues Organs 165/3-4 (pp.129-249).
2000
Wobus, A.M., E. Wolf and H.M. Beier (2000): Embryonic stem cells and nuclear transfer strategies. Cells Tissues Organs 166: 1-5.
Wobus, A.M., E. Wolf and H.M. Beier (2000): Embryonale Stammzellen und Strategien des Zellkerntransfers - Stand der Wissenschaft und Perspektiven. Reproduktionsmedizin 16: 37-42.
Kramer, J., C. Hegert, K. Guan, A.M. Wobus, P.K. Müller and J. Rohwedel (2000): Embryonic stem cell-derived chondrogenic differentiation in vitro: activation by BMP-2 and BMP-4. Mech.Dev. 92: 193-205.
Wobus, A.M., U. Wobus und B. Parthier (Hrsg.) (2000): Die Verfügbarkeit des Lebendigen. Gaterslebener Begegnung VIII, 1999, Nova Acta Leopoldina, Neue Folge Bd. 82
Vassilieva, S., K. Guan, U. Pich and A.M. Wobus (2000): Establishment of SSEA-1 and Oct-4 expressing rat ES-like cell lines and effects of cytokines of the IL-6 family on clonal growth. Exp. Cell Res. 258: 361-373.
Schönborn, F., K. Pokovic, A.M. Wobus and N. Kuster (2000): Design, optimization, realization and anlysis of an in vitro system for the exposure of embryonal stem cells at 1.71 GHz. Bioelectromagnetics 21: 372-384.
Hoch, B., A.M. Wobus, E.-G. Krause and P. Karczewski (2000): d-Ca2+/calmodulin-dependent protein kinase II expression pattern in adult mouse heart and cardiogenic differentiation of embryonic stem cells. J. Cell. Biochem. 79:293-300.
Wobus, A.M., K. Guan and J. Rohwedel (2000): Embryonic stem cell technology: loss of function/gain of function assays and developmental analysis of teratogenic factors in vitro. In: Ball, M., A.-M. van Zeller and M.E. Halder (Eds.) Progress in the Reduction, Refinement and Replacement of Animal Experimentation, Elsevier Science B.V., pp. 203-214.
Wobus, A.M. (2000): Session summary: Embryonic stem cells. In: Ball, M., A.-M. van Zeller and M.E. Halder (Eds.) Progress in the Reduction, Refinement and Replacement of Animal Experimentation, Elsevier Science B.V., pp. 201-202.
Wobus, A.M. (2000): Entwicklungspotenz embryonaler Stammzellen - Gegenwärtige und zukünftige Anwendungen. In: Klonen - Forschung und Ethik im Konflikt, Nova Acta Leopoldina, Neue Folge, Bd. 83, Nr. 318, pp.59-77.
Prelle, K., A.M. Wobus, O. Krebs, S. Staerk, W.F. Blum and E. Wolf (2000): Overexpression of insulin-like growth factor-II in mouse embryonic stem cells promotes myogenic differentiation. Biophys. Biochem. Res. Comm. 277:631-638.
Müller, M., B.K. Fleischmann, S. Frese, S. Selbert, G.J. Ji, E. Endl, G. Middeler, P. Schlenke, A.M. Wobus, J. Hescheler, H.A. Katus and W.M. Franz (2000): Selection of ventricular cardiomyocytes from ES-cells in vitro. FASEB J. 14: 2540-2548.
2001
Wobus, A.M., Guan, K. and U. Pich (2001): In vitro differentiation of embryonic stem cells and analysis of cellular phenotypes. In: Gene Knockout Protocols, Tymms, M.J. and I. Kola (Eds.), Methods Molecular Biology Series, vol. 158, Humana Press, Inc., Totowa, NJ, USA, pp. 263–286.
Schmidt, M.M., K. Guan and A.M. Wobus (2001): Lithium influences differentiation and tissue-specific gene expression of mouse embryonic stem (ES) cells in vitro, Intern. J. Dev. Biol. 45: 421-429.
Guan, K., D. Fürst and A. M. Wobus (2001): Expression and cellular distribution of av integrins in b1 integrin-deficient embryonic stem cell-derived cardiac cells. J. Mol. Cell. Card. 33: 521-532.
Wobus, A.M. (2001): Entwicklungs- und Differenzierungspotential von Stammzellen. In: Humane Stammzellen. Perspektiven und Grenzen in der regenerativen Medizin. Bundesministerium für Bildung und Forschung, Schattauer GmbH, Stuttgart, Germany, pp. 71–82.
Rolletschek, A., H. Chang, K. Guan, J. Czyz, M. Meyer and A. M. Wobus (2001): Differentiation of embryonic stem cell-derived dopaminergic neurons is enhanced by survival-promoting factors. Mech. Dev. 105:93-104.
Wobus, A.M. (2001): Potential of embryonic stem cells. Mol. Aspects of Medicine 22: 149-164.
Guan, K., H. Chang, A. Rolletschek and A. M. Wobus (2001): Embryonic stem cell-derived neurogenesis: Retinoic acid induction and lineage selection of neuronal cells. Cell & Tissue Res. 305: 171-176.
Rohwedel, J., K. Guan, C. Hegert and A. M. Wobus (2001): Embryonic stem cells as in vitro model for mutagenicity, cytotoxicity and embryotoxicity studies – Present state and future prospects. Toxicology in Vitro 15: 741-753.
Czyz, J. and A.M. Wobus (2001): Embryonic stem cell differentiation: The role of extracellular factors. Differentiation 68: 167-174
2002
Wobus, A.M., K. Guan, H.-T. Yang and K.R. Boheler (2002): Embryonic stem cells as a model to study cardiac, skeletal muscle and vascular smooth muscle cells. In: K. Turksen (Ed.) Methods Molecular Biology Series, vol. 185, Humana Press Inc., Totowa, NJ, USA, pp. 127-168.
Boheler, K. R. and A. M. Wobus (2002): Myocardial Aging and Embryonic Stem Cell Biology. In: Mattson, M.P. and G. Van Zant (Eds.) “Stem Cells: A Cellular Fountain of Youth?“, pp.141-177
Anisimov, S.V., K. Tarasov, D. Tweedie, M. D. Stern, A.M. Wobus and K.R. Boheler (2002): SAGE identification of gene transcripts with profiles unique to pluripotent mouse R1 embryonic stem cells. Genomics 79: 1-8.
Rohdewohld, H. and A.M. Wobus (2002) Embryonale Stammzellen der Maus. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 45: 113-122 (Springer-Verlag).
Wobus, A.M., U. Wobus und B. Parthier (Hrsg.) (2002): Freiheit und Programm in Natur und Gesellschaft, Gaterslebener Begegnung IX, 2001, Nova Acta Leopoldina, Neue Folge, Bd. 86, Nr. 324, Deutsche Akademie der Naturforscher Leopoldina, Halle (Saale).
Wobus, A.M. (2002): Stammzellen - Kontinuität und Plastizität im Organismus. In: Wobus, A.M., U. Wobus und B. Parthier (Hrsg.) Freiheit und Programm in Natur und Gesellschaft, Gaterslebener Begegnung IX, 2001, Nova Acta Leopoldina, Neue Folge, Bd. 86, Nr. 324, S. 49-76.
Boheler, K.R., J. Czyz, D. Tweedie, H.-T. Yang, S.V. Anisimov and A.M. Wobus (2002): Differentiation of pluripotent embryonic stem cells into cardiomyocytes. Circ. Res. 91: 189-201.
Anisimov, S.V., K. V. Tarasov, D. Riordon, A.M. Wobus and K.R. Boheler (2002): SAGE identification of differentiation responsive genes in P19 embryonic cells induced to form cardiomyocytes in vitro. Mech. Dev. 117:25-74.
Tarasov, K.V., Tarasova, Y.S., Crider, D.G., S.V. Anisimov, A.M. Wobus and K.R. Boheler (2002): Galanin and galanin receptors in embryonic stem cells: Accidental or essential? Neuropeptides 36:239-245
Hegert, C., J. Kramer, C. Oppelt, J. Müller, K. Guan, A.M. Wobus, P.K. Müller and J. Rohwedel (2002): Differentiation plasticity of chondrocytes derived from mouse embryonic stem cells. J. Cell Sci. 115:4617-4628
Gottwald, E., A.M. Wobus, K. Guan, W. Sontag, K.-F. Weibezahn, and H. Dertinger (2002) Interferential electric field treatment revealed a low increase of spontaneous cardiac differentiation but not cyclic AMP changes nor induction of cardiac-specific gene expression in pluripotent embryonal carcinoma P19 cells. Electromagn. Biol. Med. 21: 105-118.
Haverich, A., A.M. Wobus und E.-M. Engels (2002) Transplantationsmedizin: alternative Methoden zum allogenen Organersatz. In: Deutsche Forschungsgemeinschaft - Perspektiven der Forschung und ihrer Förderung. Deutsche Forschungsgemeinschaft (Hrsg.)Wiley-VCH Verlag GmbH & Co., Weinheim, S. 187-216.
2003
Wobus, A.M. (2003) Zellkulturtechniken, Zellmodelle und Tissue Engineering. In: Ganten, D. und K. Ruckpaul (Hrsg.) Grundlagen der Molekularen Medizin. 2. Auflage, Springer-Verlag Berlin-Heidelberg, S. 255-298.
Blyszczuk, P., J. Czyz, G. Kania, M. Wagner, U. Roll, L. St.-Onge and A. M. Wobus (2003) Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc. Natl. Acad. Sci. (USA) 100: 998-1003.
Kania, G., P. Blyszczuk, J. Czyz, A. Navarrete-Santos and A.M. Wobus (2003): Differentiation of mouse embryonic stem cells into pancreatic and hepatic cells. Chapter 21, In: Paul M. Wassermann and Gordon M. Keller (Eds.) Meth. Enzymol. 365: 287-303.
Czyz, J., C. Wiese, A. Rolletschek, P. Blyszczuk, M. Cross and A.M.Wobus (2003): Potential of embryonic and adult stem cells in vitro. Biol. Chem. 384:1391-409.
Draeger, A., Monastyrskaya, F.C. Burkhard, A.M. Wobus, S.E. Moss and E.B. Babiychuk (2003): Membrane segregation and downregulation of raft markers during sarcolemmal differentiation in skeletal muscle cells. Dev. Biol. 262: 324-334.
2004
Jochheim, A., T. Hillemann, G. Kania, A. Cieslak, J. Scharf, M. Attaran, M.P. Manns, A.M. Wobus and M. Ott (2004): Quantitative gene expression profiling reveals a fetal hepatic phenotype of murine ES-derived hepatocytes. Int. J. Dev. Biol. 48(1):23-9.
Kania, G., P. Blyszczuk, A. Jochheim, M. Ott and A.M. Wobus (2004): Generation of glycogen- and albumin-producing hepatocyte-like cells from embryonic stem cells. Biol. Chem. 385: 943-953.
Blyszczuk, P. and A.M. Wobus (2004) Stem cells and pancreatic differentiation. J. Biotech. 113: 3-13.
Kania, P. Blyszczuk, & A.M. Wobus (2004) The generation of insulin-producing cells from embryonic stem cells - a discussion of controversial findings. Int. J. Dev. Biol. 48: 1061-1064.
Blyszczuk, P., A. Rozzo, C. Asbrand, G. Kania, L. St-Onge, M. Rupnik & A.M. Wobus (2004): Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells. Int. J. Dev. Biol. 48: 1095-1104.
Czyz, J., K. Guan, Q. Zeng, T. Nikolova, A. Meister, F. Schönborn, J. Schuderer, N. Kuster and A.M. Wobus (2004): High-frequency electromagnetic fields (GSM signals) affect gene expression levels in tumor suppressor p53-deficient embryonic stem cells. Bioelectromagnetics 25(4):296-307.
Czyz, J., T. Nikolova, J. Schuderer, N. Kuster and A.M. Wobus (2004): Non-thermal effects of power-line magnetic fields (50 Hz) on gene expression levels of pluripotent embryonic stem cells - the role of tumor suppressor p53. Mutat Res. 557(1):63-74.
Rolletschek, A., P. Blyszczuk and A.M. Wobus (2004). Embryonic stem cell-derived cardiac, neuronal and pancreatic cells as model systems to study toxicological effects. Toxicol Lett. 149(1-3):361-9.
Wiese, C., A. Rolletschek, G. Kania, P. Blyszczuk, K.V. Tarasov, Y. Tarasova, R.P. Wersto, K.R. Boheler, and A.M. Wobus (2004): Nestin expression - a property of multi-lineage progenitor cells? Cell Mol Life Sci 61: 2510-2522.
Wobus, A.M., U. Wobus und B. Parthier (Hrsg.) (2004): Bewahren und Verändern im Kontext biologischer und kultureller Evolution, Gaterslebener Begegnung X, 2003, Nova Acta Leopoldina, Neue Folge, Bd. 90, Nr. 338, Deutsche Akademie der Naturforscher Leopoldina, Halle (Saale).
2005
Czyz, J., K. Guan, Q. Zeng & A.M. Wobus (2005) Loss of beta1 integrin function results in upregulation of connexin expression in embryonic stem cell-derived cardiomyocytes. Int. J. Dev. Biol. 49(1):33-41.
Kania, G., D. Corbeil, J. Fuchs, K.V. Tarasov, P. Blyszczuk, W.B. Huttner, K.R. Boheler & A.M. Wobus (2005) Somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors. Stem Cells 23(6):791-804.
Pelz, O., M. Wu, T. Nikolova, M. Kamprad, M. Ackermann, D. Egger, F. Emmrich, A.M. Wobus & M. Cross (2005) Duplex polymerase chain reaction quantification of human cells in a murine background. Stem Cells 23(6):828-833.
Rolletschek, A., C. Wiese and A.M. Wobus (2005): In vitro culture and differentiation of mouse embryonic stem cells. Chapter 25, In: Mari-Beffa, M. and Knight, J. (Edts.) "Key Experiments in Practical Developmental Biology". Cambridge University Press, Cambridge, UK, pp. 316-329.
Wobus, A.M. & K.R. Boheler (2005) Embryonic stem cells: prospects for developmental biology and cell therapy. Physiol. Rev. 85(2):635-678.
Wiese, C., G. Kania, A. Rolletschek, P. Blyszczuk & A.M. Wobus (2005) Pluripotency - Capacity for In Vitro Differentiation of Undifferentiated Embryonic Stem Cells. In S. Pells (Ed.) Nuclear Reprogramming - Methods and Protocols. Humana Press, Totowa, USA, vol: 325, pp. 181-205.
Hucho, F., K. Brockhoff, W. van den Daele, K. Köchy, J. Reich, H.J. Rheinberger, B. Müller-Röber, K. Sperling, A.M. Wobus, M. Boysen & M. Kölsch (2005) Gentechnologiebericht – Analyse einer Hochtechnologie in Deutschland. Herausgegeben von der Berlin-Brandenburgischen Akademie der Wissenschaften, Elsevier Spektrum Akademischer Verlag, München.
Nikolova, T., J. Czyz, A. Rolletschek, P. Blyszczuk, J. Fuchs, G. Jovtchev, J. Schuderer, N. Kuster & A.M. Wobus (2005) Electromagnetic fields affect transcript levels of apoptosis-related genes in embryonic stem cell-derived neural progenitor cells. FASEB J. 19: 1686-1688. FASEB J. Express.fasebj org/cgi/doi/10.1096/fj.04-3549fje; doi: 10.1096/fj.04-3549fje.
Tarasov, K.V., S.V. Anisimov, Y.S. Tarasova, D.R. Riordon, A. Younes, M. D. Stern, A.M. Wobus & K.R. Boheler (2005) SAGE analysis of embryonic stem cells. In: San Ming Wang (ed.) SAGE: Current Technologies and Applications. Chapter 11, 207-228.
2006
Blyszczuk, P. & A.M. Wobus (2006) In vitro differentiation into the pancreatic lineage. In: Turksen, K. (ed.) "Embryonic Stem Cells II: Methods and Protocols", Methods in Molecular Biology vol. 330, Humana Press Inc. Totowa, N.J., USA pp. 373-385.
Wobus, A.M. & K.R. Boheler (eds.) (2006) Handbook of Experimental Pharmacology, vol.174, Special Issue "Stem Cells", Springer Berlin Heidelberg New York, pp. 1-414.
Schroeder, I., A. Rolletschek, P. Blyszczuk, G. Kania & A.M. Wobus (2006) Differentiation of mouse embryonic stem cells to insulin-producing cells. Nature Protocols 1(2): 495-507.
Blyszczuk, P., G. Kania & A.M. Wobus (2006) In vitro differentiation of mouse ES cells into pancreatic and hepatic cells. In: Notarianni, E. and M.J. Evans (eds.) Embryonic Stem cells - A Practical Approach. Oxford University Press, pp.218-237.
Wiese, C., A. Rolletschek, G. Kania, A. Navarrete-Santos, S.V. Anisimov, B. Steinfarz, K.V. Tarasov, S.A. Brugh, I. Zahanich, C. Rüschenschmidt, H. Beck, P. Blyszczuk, J. Czyz, J.F. Heubach, U. Ravens, O. Horstmann, L. St-Onge, T. Braun, O. Brüstle, K.R. Boheler, & A.M. Wobus (2006) Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin-positive cells with proliferation and multilineage differentiation capacity in vitro. Stem Cells 24(9) 2085-2097.
Wobus, A.M., F. Hucho, W. van den Daele, K. Köchy, J. Reich, H.-J. Rheinberger, B. Müller-Röber, K. Sperling, M. Boysen & M. Kölsch (2006) Stammzellforschung und Zelltherapie - Stand des Wissens und der Rahmenbedingungen in Deutschland. Mit Beiträgen von Christine Hauskeller und Jochen Taupitz. Supplement zum Gentechnologiebericht. Herausgegeben von der Berlin-Brandenburgischen Akademie der Wissenschaften, Elsevier Spektrum Akademischer Verlag, München 295 S.
Haberland, A., F.N. Gellerich, A.M. Wobus & M.H.P. Wussling (2006) Calcium signals in cardiac myocytes derived from mouse embryonic stem cells. Medical news (Nowiny Lekarskie) 75, Suppl. II: 22-28.
Schroeder, I.S., G. Kania, P. Blyszczuk, & A.M. Wobus (2006) Insulin-producing cells. Methods in Enzymology, vol. 418, chapter 19, Elsevier Inc. pp. 315-333.
Wobus, A.M. (2006) Stammzellforschung - Perspektiven und Probleme in Deutschland. Akademievorlesung, Berlin-Brandenburgische Akademie, Berichte und Abhandlungen Band 12, Akademie Verlag, pp. 63-76.
Rolletschek, A., G. Kania & A.M. Wobus (2006) Generation of pancreatic insulin-producing cells from embryonic stem cells - 'Proof-of-principle', but questions still unanswered. Diabetologia 49(11) 2541-2545.
Tonack, S., A. Rolletschek, A.M. Wobus, B. Fischer & A Navarrete Santos (2006) Differential expression of glucose transporter isoforms during embryonic stem cell differentiation. Differentiation 74:499-509.
ter Meulen, V. & A.M. Wobus (eds.) (2006) "International Conference: Embryonic and Somatic Stem Cells – Regenerative Systems for Cell and Tissue Repair", Nova Acta Leopoldina, Neue Folge, Bd. 95, Nr. 352, 420 S.
Wiese, C., G. Kania G, A. Rolletschek, P. Blyszczuk & A.M. Wobus (2006) Pluripotency: capacity for in vitro differentiation of undifferentiated embryonic stem cells. Methods in Molecular Biology vol. 325, Humana Press Inc. Totowa, N.J., USA pp. 181-205.
Wobus, A.M. (2006) Gegenwärtiger Stand und Probleme der Stammzellforschung in Deutschland. In: Wink, R. (Hrsg.) Deutsche Stammzellpolitik im Zeitalter der Transnationalisierung. Nomos Verlagsgesellschaft Baden-Baden, S.9-21.
2007
Nikolova, T., M. Wu, K. Brumbarov, R. Alt, H. Opitz, K.R. Boheler, M. Cross & A.M. Wobus (2007) WNT-conditioned media differentially affect the proliferation and differentiation of cord blood-derived CD133+ cells in vitro. Differentiation 75(2):100-11.
Kleger, A., T. Busch, S. Liebau, K. Prelle, S. Paschke, M. Beil, A. Rolletschek, A.M. Wobus, E. Wolf, G. Adler & T. Seufferlein (2007) The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukemia cells. Cellular Signalling 19: 367-377.
Löser, P. & A.M. Wobus (2007) Aktuelle Entwicklungen in der Forschung mit humanen embryonalen Stammzellen. Naturwiss. Rundsch. 5: 229-240.
Gottwald, E., S. Gieselbrecht, C. Augspurger, N. Dambrowsky, R. Truckenmüller, V. Piotter, T. Gietzelt, O. Wentdt, W. Pfleging, A. Welle, A. Rolletschek, A.M. Wobus & K.F. Weibezahn (2007) A chip-based platform for the in vitro generation of tissues in three-dimensional organization. Lab Chip 7: 777-785.
Tonack, S., K. Kind, J.G. Thompson, A.M. Wobus, B. Fischer & A. Navarrete Santos (2007) Dioxin affects glucose transport via the arylhydrocarbon receptor signal cascade in pluripotent embryonic carcinoma cells. Endocrinology 148 (12) 5902-5912.
Wobus, A.M. (2007) Embryonic and somatic stem cells – Regenerative Systems for Cell and Tissue repair – Tagungsbericht und Ausblick. Jahrbuch der Deutschen Akademie der Naturforscher Leopoldina (Halle/S.) LEOPOLDINA (R. 3) 52: 281-285.
2008
Ruau, D., Ensenat-Waser, R., Dinger, T. C., Vallabhapurapu, D. S., Rolletschek, A., Hacker, C., Hieronymus, T., Wobus, A.M., Müller, A.M., and Zenke, M. (2008) Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. Stem Cells 26: 920-926.
Tarasov, K.V., Y.S. Tarasova, W.L. Tam, D.R. Riodon, S.T. Elliott, G. Kania, J. Li, S. Yamanaka, D.G. Crider, G. Testa, R.A. Li, B. Lim, C.L. Stewart, Y. Liu, J.E. Van Eyk, R.P. Wersto, A.M. Wobus & K.R. Boheler (2008). B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells. PLoS ONE 3 (6):e2478 18575582.
Hieronymus, T., Ruau, D., Ober-Blöbaum, J., Baek, J.-H., Rolletschek, A., Rose-John, S., Wobus, A.M., Müller, A.M., and Zenke, M. (2008) The transcription factor repertoire of Flt3+ hematopoietic stem cells. Cells Tissues Organs 188: 103-115.
Tarasov, K.V., G. Testa, Y.S. Tarasova, G. Kania, D.R. Riordon, M. Volkova, A.M. Wobus & K.R. Boheler (2008). Linkage of pluripotent stem cell-associated transcripts to regulatory gene networks. Cells Tissues Organs 188: 31-45.
Yamanaka, S., J.Li, G. Kania, S. Elliot, R.P. Wersto, J. van Eyck, A.M. Wobus and K.R. Boheler (2008). Pluripotency of Embryonic Stem Cells. Cell Tissue Res. 331: 5-22.
Wobus, A.M. (2008) Reversibilität des Entwicklungsstatus menschlicher Zellen. Stammzellforschung, Potentialitätsprinzip und ethisch-rechtliche Konsequenzen Naturwiss. Rdsch. 61: 221-225.
Löser, P., Guhr, A., Kurtz, A. and Wobus, A.M. (2008) Additional considerations relevant to meta analyses of hESC publication data. Cell Stem Cell 3: 129-130.
Perino, M.G., S. Yamanaka, J Li, Wobus, A.M. and K.R. Boheler (2008) Cardiomyogenic stem and progenitor cell plasticity and the dissection of cardiopoiesis. J. Mol. Cell. Cardiol. 45:475-494.
Kuhn, H.-G., Bruestle, O., Martens, U.W. and Wobus, A.M. (Guest Editors) Cell & Tissue Research vol. 331(1): STEM CELLS: Established facts, Open issues, and Future directions. Springer-Verlag Berlin Heidelberg (2008), pp. 372.
Kuhn, G., Bruestle, O., Martens, U.W., Wobus, A.M. and K. Unsicker (2008) Stem Cells: Established facts, open issues and future directions. Cell Tissue Res. 331(1): 1-3
Wobus, A.M. (2008) Stem Cell Research within the Priority Program 1109 of the German Research Foundation, 2001-2007. Cells Tissues Organs 188: 6-8.
Wobus, A.M. and Löser, P. (2008) Humane embryonale Stammzellen im Kontext internationaler Forschungsaktivitäten. Bundesgesundheitsblatt 51(9):994-1004.
Wobus, A.M., & Boheler, K.R. (Eds.) Handbook of Experimental Pharmacology 174, 2nd ed., Springer-Verlag Berlin-Heidelberg (2008) pp.416.
Wobus, A.M. & Mertsching, H. (2008) Zellkulturtechniken, Zellmodelle und Tissue Engineering. In: Ganten, D. & Ruckpaul, K. (Eds.): Grundlagen der Molekularen Medizin. Springer-Verlag Berlin-Heidelberg, pp. 38-70.
2009
Wobus, A.M. (2009) Reprogrammierung und induzierte Pluripotenz bei Säugerzellen. IPK Journal 18, 1. Sonderheft April 2009, S. 6-8.
Marchand M., I.S. Schroeder, S. Markossian, A. Skoudy, D. Negre, F.-L. Cosset, P. Real, C. Kaiser, A.M. Wobus & P. Savatier P (2009) Mouse ES cells over-expressing the transcription factor NeuroD1 show increased differentiation towards endocrine lineages and insulin-expressing cells. Int. J. Dev. Biol. 53: 569-578.
Schulz, H., R. Kolde, P. Adler, I. Aksoy, K. Anastassiadis, M. Bader, N. Billon, H. Boeuf, P.-Y. Bourillot, F. Buchholz, C. Dani, M. X. Doss, O. Feraud, L. Forrester, R. Friel, M. Gitton, D. Henrique, J. Hescheler, H. Himmelbauer, N. Huebner, E. Karantzali, A. Kretsovali, S. Lubitz, L. Pradier, J. reimand, A. Rolletschek, A. Sachinidis, P. Savatier, F. Stewart, M.P. Storm, M. Trouillas, J. Villo, M.J. Welham, J. Winkler, A. Wobus & A.K. Hatzopoulos (2009): The FunGenES database: A genomics resource for mouse embryonic stem cell differentiation. PloS One 4, issue 9/ e6804.
Sulzbacher, S., I.S. Schroeder, T.T. Truong & A.M. Wobus: Activin A-induced differentiation of embryonic stem cells into endoderm and pancreatic progenitors – The influence of differentiation factors and culture conditions. Stem Cell Rev. 5: 159-173.
Schroeder, I., C. Wiese, T. Truong, A. Rolletschek & A. M. Wobus (2009) Differentiation analysis of pluripotent mouse embryonic stem (ES) cells in vitro. Chapter 12, In: Kuehn, W. & Wurst, W. (Eds.): Gene Knockout Protocols: Second Edition (Methods Mol. Biol., vol. 530) Humana Press, Totowa/USA, pp. 219-250.
Schroeder, I.S., S. Sulzbacher, T.T. Truong, P. Blyszczuk, G. Kania & A.M. Wobus (2009) Insulin-producing cells from mouse embryonic stem cells. Chapter 23, In: Lanza, R. & I. Klimanskaya (Eds.): Essential Stem Cell Methods, Elsevier AP, Amsterdam, pp. 478-501.
Rolletschek, A. & A.M.Wobus (2009) Induced pluripotent stem cells: Promises and open questions. Biol. Chem 390: 845-849.
Wobus, A.M. & U. Wobus: Gaterslebener Gespräch 2008 zum Thema „Programmierung und Reprogrammierung“, IPK Journal 18 (2009), 1. Sonderheft, April 2009.
Wiese, C., T. Nikolova, I. Zahanich, S. Sulzbacher, J. Fuchs, S. Yamanaka, E. Graf, U. Ravens, K.R. Boheler and A.M.Wobus: Differentiation induction of mouse embryonic stem cells intu sinus node-like cells by suramin. Int. J. Cardiol. (2009), doi: 10.1016/j.ijcard.2009.08.021
Müller-Röber, B., M. Boysen, B. Fehse, F. Hucho, K. Köchy, J. Reich, H.-J. Rheinberger, H.-H. Ropers, K. Sperling & A.M.Wobus (2009) Zweiter Gentechnologiebericht – Analyse einer Hochtechnologie in Deutschland, Forschungsberichte der Arbeitsgruppe der Berlin-Brandenburgischen Akademie der Wissenschaften, Bd. 23, Forum W – Wissenschaftlicher Verlag Dornburg, pp. 464.
2010
Loeser, P., J. Schirm, A. Guhr, A.M. Wobus & A. Kurtz (2010): Human embryonic stem cell lines and their use in international research. Stem Cells 28: 240-246.
Rolletschek, A., I.S. Schroeder, H. Schulz, O. Hummel, N. Huebner & A.M. Wobus (2010): Characterization of mouse embryonic stem cell differentiation into the pancreatic lineage in vitro by transcriptional profiling, quantitative RT-PCR and immunocytochemistry. Int. J. Dev. Biol. 54: 41-54.
Seufert, G., Päth, G., Feilen, P., Krautz, C., Schröder, I., Wobus, A.M., Lammert, E. und Solimena, M. (2010): Mechanismen und Methoden der Regeneration und des Ersatzes von Insulin produzierenden Beta-Zellen des endokrinen Pankreas bei Diabetes mellitus. Med. Welt 61: 87-93.
Wobus, AM. (2010): The Janus face of pluripotent stem cells: Connection between pluripotency and tumourigenicity. BioEssays 32: 993-1002.
Kleger, A., Seufferlein, T., Malan, D., Tischendorf, M., Storch, A., Wolheim, A., Latz, S., Protze, S., Porzner, M., Proepper, C., Brunner, C., Katz, S.-F., Varma Pusapati, G., Bullinger, L., Franz, W.-M., Koehntop, R., Giehl, K., Spyrantis, A., Wittekindt, O., Lin, Q., Zenke, M., Fleischmann, B.K., Wartenberg, M., Wobus, A.M., Boeckers, T.M. & Liebau, S. (2010): Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Circulation 122 (18): 1823-1836.
Wobus, A.M. und Wobus, U. (2010) Gaterslebener Begegnung 2009. Der Begriff der Natur – Wandlungen unseres Naturverständnisses und seine Folgen. Jahrbuch 2009 der Deutschen Akademie der Naturforscher Leopoldina (Halle/Saale) LEOPOLDINA (R.3) 55: 419-420.
2011
Wiese, C., Nikolova, T., Zahanich, I., Sulzbacher, S., Fuchs, J. Yamanaka, S., Graf, E., Boheler, K.R. & Wobus, A.M. (2011): Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin. Int. J. Cardiology 147: 95-111.
Wobus, A.M. and Loeser, P. (2011) Present state and future perspectives of using pluripotent stem cells in toxicology research. Arch. Toxicol. 85 (2): 79-117. DOI 10.1007/s00204-010-0641-6.
Löser, P., Hanke, B. und Wobus, A.M. (2011) Humane pluripotente Stammzellen: Perspektiven ihrer Nutzung und Forschung in Deutschland. Naturwiss. Rdsch. 64(9): 453-465.
2012
Wobus, A.M. and Loeser, P. Stem cell research in Germany with specific regard to human embryonic stem cells. In: Mazzolini, R.G. and Rheinberger, H.-J. (Eds.): Differing routes to stem cell research: Germany and Italy. Fondazione Bruno Kessler Istituto storico italo-germanico (Italienisch-Deutsches Historisches Institut), Contributi 26, pp. 165-187, Societa editrice il Mulino, Bologna, and Duncker & Humblot, Berlin (2012).
Schroeder, I.S., Sulzbacher, S., Nolden, T., Fuchs, J., Czarnota, J., Meisterfeld, R., Himmelbauer, H. and Wobus, A.M. (2012): Induction and selection of Sox17-expressing endoderm cells generated from murine embryonic stem cells. Cells Tissues Organs 195(6): 507-523 (2012).
Schroeder, I.S., Daniel-Wojcik, A. & Wobus, A.M. (2012): Strategies for pancreatic differentiation of pluripotent stem cells. Part II, pp. 177- 188. In: Jenkins, N., N. Barron and P.M. Alves (Eds.) Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT proceedings vol. 5), Dublin, Ireland, June 7-10, 2009, Springer Dordrecht, Heidelberg London New York (2012)
Loeser, P., Guhr, A., Kobold, S., Wobus, A.M. and Kurz, A. (2012): Status and impact of research on human pluripotent stem cells: Cell lines and their use in published research. In: Hayat, M.A. (Ed.): Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury, vol. 2, pp. 61-74, Springer Dordrecht, Heidelberg, London, New York (2012).
Müller, M., Stockmann, M., Malan, D., Wolheim, A., Tischendorf, M. Linta, L., Katz, S.-F., Lin, Q., Latz, S., Brunner, C., Wobus, A.M., Zenke, M., Wartenberg, M., Böckers, T.M., von Wichert, G., Fleischmann, B.K., Liebau, S. and Kleger, A. (2012): Ca2+-activated K channels – New tools to induce cardiac commitment from pluripotent stem cells in mice and men. Stem Cell Rev Rep 8(3): 720-740 (2012).
Wobus, A.M., Wobus, U. und Parthier, B. (Hrsg.): Wachstum und Reifung in Natur und Gesellschaft, Gaterslebener Begegnung 2011, Nova Acta Leopoldina, Neue Folge, Bd. 115, Nr. 393, 287 S., Wissenschaftliche Verlagsgesellschaft Stuttgart (2012).
Wobus, A.M. und Wobus, U.: 25 Jahre Gaterslebener Begegnungen – ein persönlicher Rückblick. In: Wobus, A.M., Wobus, U. und Parthier, B. (Hrsg.): Wachstum und Reifung in Natur und Gesellschaft, Gaterslebener Begegnung 2011, Nova Acta Leopoldina, Neue Folge, Bd. 115, Nr. 393, S. 265-278 (2012).